2024
Dilly GA, Blednov YA, Warden AS, Ezerskiy L, Fleischer C, Plotkin JD, Patil S, Osterndorff-Kahanek EA, Mayfield J, Mayfield RD, Homanics GE, Messing RO (2024) Knockdown of Tlr3 in dorsal striatum reduces ethanol consumption and acute functional tolerance in male mice. Brain Behav Immun 118:437-448. PMCID:In Process. Download Article.
Homanics GE, Park JE, Bailey L, Schaeffer DJ, Schaeffer L, He J, Li S, Zhang T, Haber A, Spruce C, Greenwood A, Murai T, Schultz L, Mongeau L, Ha SK, Oluoch J, Stein B, Choi SH, Huhe H, Thathiah A, Strick PL, Carter GW, Silva AC, Sukoff Rizzo SJ (2024). Early molecular events of autosomal-dominant Alzheimer’s disease in marmosets with PSEN1 mutations. Alzheimers Dement. 10.1002/alz.13806. PMCID: In Process. Download Article.
Plasil SL, Farris SP, Blednov Y, Mayfield RD, Mangieri RA, Nwokeji UJ, Aziz HC, Lambeth PS, Harris RA, Homanics GE (2024) Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice. Genes Brain Behav 23:e12886. PMCID: PMC PMC10876150. Download Article.
Rice RC, Gil DV, Baratta AM, Frawley RR, Hill SY, Farris SP, Homanics GE (2024) Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior. Neurobiology of Stress 29:100603. PMCID: PMC10792982. Download Article.
2023
Chang DS, Littlepage-Saunders M, Hochstein MJ, Matteo CJ, Amelga K, Homanics GE, Johnson KA (2023) Assessment of behavioral flexibility in mice with conditional deletion of metabotropic glutamate receptor 2 from Emx1 lineage neurons. bioRxiv:2023.2009.2015.558004.
Kambali M, Li Y, Unichencko P, Pliego JF, Yadav R, Liu J, McGuinness P, Cobb JG, Wang M, Nagarajan R, Lyu J, Vongsouthi V, Jackson CJ, Engin E, Coyle JT, Shin J, Talkowski ME, Homanics GE, Bolshakov VY, Henneberger C, Rudolph U. (2023) A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampus. bioRxiv:2023.05.29.542745. PMCID: PMC10312439
Okhuarobo A, Kreifeldt M, Gandhi PJ, Lopez C, Martinez B, Fleck K, Bajo M, Bhattacharyya P, Dopico AM, Roberto M, Roberts AJ, Homanics GE, Contet C (2023) Ethanol’s interaction with BK channel alpha subunit residue K361 does not mediate behavioral responses to alcohol in mice. Mol Psychiatry. DOI: 10.1038/s41380-023-02346-y. Download Article.
Sukoff Rizzo SJ, Homanics G, Schaeffer DJ, Schaeffer L, Park JE, Oluoch J, Zhang T, Haber A, Seyfried NT, Paten B, Greenwood A, Murai T, Choi SH, Huhe H, Kofler J, Strick PL, Carter GW, Silva AC (2023) Bridging the rodent to human translational gap: Marmosets as model systems for the study of Alzheimer’s disease. Alzheimers Dement (N Y) 9:e12417. PMCID: PMC10442521. Download Article.
2022
Baratta, A. M., Mangieri, R. A., Aziz, H. C., Lopez, M. F., Farris, S. P., & Homanics, G. E. (2022). Effect of chronic intermittent ethanol vapor exposure on RNA content of brain-derived extracellular vesicles. Alcohol 105: 9-24. Download Article.
Huang, Y., Rafael Guimarães, T., Todd, N., Ferguson, C., Weiss, K. M., Stauffer, F. R., McDermott, B., Hurtle, B. T., Saito, T., Saido, T. C., MacDonald, M. L., Homanics, G. E., & Thathiah, A. (2022). G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model. Proceedings of the National Academy of Sciences, 119(40), e2204828119. Download Article.
Myers, T.D., Ferguson, C., Gliniak, E., Homanics, G.E., and Palladino, M.J. (2022). Murine model of triosephosphate isomerase deficiency with anemia and severe neuromuscular dysfunction. Current Research in Neurobiology 3: 100062. Download Article.
Plasil, S.L., Collins, V.J., Baratta, A.M., Farris, S.P., and Homanics, G.E. (2022). Hippocampal ceRNA networks from chronic intermittent ethanol vapor-exposed male mice and functional analysis of top-ranked lncRNA genes for ethanol drinking phenotypes. Advances in Drug and Alcohol Research 2: 10831. Download Article.
2021
Baratta, A.M., Rathod, R.S., Plasil, S.L., Seth, A., and Homanics, G.E. (2021). Exposure to drugs of abuse induce effects that persist across generations. International Review of Neurobiology 156: 217-277. Download Article.
Figueroa, A.G., Benkwitz, C., Surges, G., Kunz, N., Homanics, G.E., and Pearce, R.A. (2021). Hippocampal beta2-GABAA receptors mediate LTP suppression by etomidate and contribute to long-lasting feedback but not feedforward inhibition of pyramidal neurons. J Neurophysiol 126: 1090-1100. Download Article.
Gallegos, S., San Martin, L., Araya, A., Lovinger, D.M., Homanics, G.E., and Aguayo, L.G. (2021). Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor. Neuropsychopharmacology 46, 528-536. Download Article.
Goldberg, L.R., Yao, E.J., Kelliher, J.C., Reed, E.R., Wu Cox, J., Parks, C., Kirkpatrick, S.L., Beierle, J.A., Chen, M.M., Johnson, W.E., Homanics, G.E., Williams, R.W., Bryant, C.D., Mulligan, M.K. (2021). A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity. Genes Brain Behav 20: e12774. Download Article.
Grubisha, M.J., Sun, T., Eisenman, L., Erickson, S.L., Chou, S.Y., Helmer, C.D., Trudgen, M.T., Ding, Y., Homanics, G.E., Penzes, P., Wills, Z.P., Sweet, R.A. (2021). A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development. Proc Natl Acad Sci U S A 118: e2022546118. Download Article.
Grubisha, M.J., Sun, X., MacDonald, M.L., Garver, M., Sun, Z., Paris, K.A., Patel, D.S., DeGiosio, R.A., Lewis, D.A., Yates, N.A., Camacho, C., Homanics, G.E., Ding, Y., Sweet, R.A. (2021). MAP2 is differentially phosphorylated in schizophrenia, altering its function. Mol Psychiatry 26: 5371-5388. Download Article.
Hawkins, N.A., Nomura, T., Duarte, S., Barse, L., Williams, R.W., Homanics, G.E., Mulligan, M.K., Contractor, A., and Kearney, J.A. (2021). Gabra2 is a genetic modifier of Dravet syndrome in mice. Mamm Genome 32: 350-363. Download Article.
Saba, L.M., Hoffman, P.L., Homanics, G.E., Mahaffey, S., Daulatabad, S.V., Janga, S.C., and Tabakoff, B. (2021). A Long Non-Coding RNA (LRAP) Modulates Brain Gene Expression and Levels of Alcohol Consumption in Rats. Genes Brain Behav 20: e12698. Download Article.
Zamudio, P.A., Gioia, D.A., Lopez, M., Homanics, G.E., and Woodward, J.J. (2021). The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits. Psychopharmacology (Berl) 238: 271-279. Download Article.
2020
Johnson K, Liput D, Homanics GE, Lovinger D (2020) Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure. Alcohol 82: 11-21. Download Article
Munoz B, Gallegos S, Peters C, Murath P, Lovinger DM, Homanics GE, Aguayo LG (2020) Influence of non-synaptic alpha1 glycine receptors on ethanol consumption and place preference. Addiction Biology 25: e12726. Download Article
Plasil SL, Seth A, Homanics GE (2020) CRISPR Turbo Accelerated Knock Out (CRISPy TAKO) for rapid in vivo screening of gene function.
Frontiers in Genome Editing 2: 12. Download Article.
Rathod, R.S., Ferguson, C., Seth, A., Baratta, A.M., Plasil, S.L., and Homanics, G.E. (2020). Effects of paternal preconception vapor alcohol exposure paradigms on behavioral responses in offspring. Brain Sci 10, E658. Download Article
Rompala GR, Ferguson C, Homanics GE (2020) Coincubation of sperm with epididymal extracellular vesicle preparations from chronic intermittent ethanol-treated mice is sufficient to impart anxiety-like and ethanol-induced behaviors to adult progeny. Alcohol 87: 111-120. Download Article
Zamudio P, Smothers CT, Homanics GE, Woodward JJ (2020) Knock-in mice expressing an ethanol-resistant GluN2A NMDA receptor subunit show altered responses to ethanol. Alcoholism Clinical Experimental Research 44: 479-491. Download Article
2019
Beeler E, Nobile L, and Homanics, GE (2019) Paternal preconception every-other-day ethanol drinking alters behavior and ethanol consumption in offspring. Brain Sciences 9: 56. Download Article
Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA (2019). Scn4b regulates the hypnotic effects of ethanol and other sedative drugs. Genes Brain & Behavior, e12562. Download Article
Harmon DB, Mandler WK, Sipula IJ, Dedousis N, Lewis SE, Eckels JT, Du J, Wang Y, Huckestein BR, Pagano PJ, Ciefuentes-Pagano E, Homanics GE, Van’t Erve TJ, Stefanovic-Racic M, Jurczak MJ, O’Doherty RM, Kelley EE (2019) Hepatocyte-specific ablation or whole body inhibition of xanthine oxidoreductase in mice corrects obesity-induced systemic hyperuricemia without improving metabolic abnormalities. Diabetes 68: 1221-1229. Download Article
Homanics, GE (2019) Gene edited CRISPy Critters for alcohol research. Alcohol: 74: 11-19. Download Article
Mulligan MK, Abreo TJ, Neuner SM, Parks CL, Watkins CE, Houseal MT, Shapakeer T, Hook M, Tan H, Wang X, Ingels J, Peng J, Lu L, Kaczorowski CC, Bryant CD, Homanics GE, Williams RW (2019) Identification of a functional non-coding variant in the GABAA receptor α2 subunit of the C57BL/6J mouse reference genome: Major implications for neuroscience research.. Frontiers in Genetics 10: 188. Download Article
Rompala GR, and Homanics GE (2019). Intergenerational effects of alcohol: a review of paternal preconception ethanol exposure studies and epigenetic mechanisms in the male germline. Alcoholism Clinical and Experimental Research 43: 1032-1045. Download Article
2018
Zamudio-Bulcock PA, Homanics GE, Woodward JJ (2018) Loss of Ethanol inhibition of NMDAR-mediated currents and plasticity of cerebellar synapses in mice expressing the GluN1(F639A) subunit. Alcohol Clin Exp Res: 42: 698-705. Download Article
Varodayan FP, Khom S, Patel RR, Steinman MQ, Hedges DM, Oleata CS, Homanics GE, Roberto M, Bajo M (2018) Role of TLR4 in the modulation of central amygdala GABA transmission by CRF following restraint stress. Alcohol and Alcoholism: 53: 642-649. Download Article
Rompala GR, Simmons A, Kihle B, Homanics GE (2018) Paternal preconception chronic variable stress confers attenuated ethanol drinking behavior selectively to male offspring in a pre-stress environment dependent manner. Frontiers in Behavioral Neuroscience: 12: 257. Download Article
Rompala GR, Mounier A, Wolfe CM, Lin Q, Lefterov I, Homanics GE (2018) Heavy chronic intermittent ethanol exposure alters small noncoding RNAs in mouse sperm and epididymosomes. Frontiers in Genetics 9: 32. Download Article
Lu J, Fan S, Zou G, Hou Y, Pan T, Guo W, Yao L, Du F, Homanics GE, Liu D, Zhang L, Xiong W (2018) Involvement of glycine receptor alpha1 subunits in cannabinoid-induced analgesia. Neuropharmacology 133:224-232. Download Article
2017
Yocum GT, Turner DL, Danielsson J, Barajas MB, Zhang Y, Xu D, Harrison N, Homanics GE, Farber DL, Emala CW, Sr. (2017) GABAA receptor alpha4 subunit knockout enhances lung inflammation and airway reactivity in a murine asthma model. Am J Physiol Lung Cell Mol Physiol 313: L406-L415. PMCID: PMID 28473323. Download Article
Rompala GR, Finegersh A, Slater M, Homanics GE (2017) Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background. Alcohol 60:169-178. PMCID: PMC5419883. Download Article
Pratt CP, Kuljis DA, Homanics GE, He J, Kolodieznyi D, Dudem S, Hollywood MA, Barth AL, Bruchez MP (2017) Tagging of endogenous BK channels with a fluorogen-activating peptide reveals beta4-mediated control of channel clustering in cerebellum. Front Cell Neurosci 11:337. PMCID: PMC5671578. Download Article
Mahnke AH, Miranda RC, Homanics GE (2017) Epigenetic mediators and consequences of excessive alcohol consumption. Alcohol 60:1-6. PMCID: PMC543921. Download Article
Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE (2017) The sodium channel β4 auxiliary subunit selectively controls long-term depression in core nucleus accumbens medium spiny neurons. Front Cell Neurosci 11:17. PMCID: PMC5303751. Download Article
Hill S, Romapal G, Homanics GE, Zezza N (2017) Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring. Epigenomics 9: 1189-1203. PMCID: PMC5585841. Download Article
Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt J, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE (2017) Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents. J Neurosci 37:1139-1155. PMCID: PMC5296793. Download Article
den Hartog CR, Gilstrap M, Eaton B, Lench DH, Mulholland PJ, Homanics GE, Woodward JJ (2017) Effects of repeated ethanol exposures on NMDA receptor expression and locomotor sensitization in mice expressing ethanol resistant NMDA Receptors. Front Neurosci 11:84. PMCID: PMC5318453. Download Article
Blednov YA, Borghese CM, Ruiz CI, Cullins MA, Da Costa A, Osterndorff-Kahanek EA, Homanics GE, Harris RA (2017) Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination. Neuropharmacology: 123: 201-209. PMCID: PMC5543808. Download Article
2016
Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C, Homanics GE, Cao G, Bennett MV, Chen J (2016) APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury. Proc Natl Acad Sci USA 113:E3558-E3567. PMCID: PMC4922172 Download Article
Rompala GR, Finegersh A, Homanics GE (2016) Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice. Alcohol 53:19-25. PMCID: PMC 4904231 Download Article
Finegersh A, Homanics GE (2016) Chromatin immunoprecipitation and gene expression analysis of neuronal subtypes after fluorescence activated cell sorting. J Neurosci Methods 263:81-88. PMCID: PMC 4801782 Download Article
Cai X, Huang H, Kuzirian MS, Snyder LM, Matsushita M, Lee MC, Ferguson C, Homanics GE, Barth AL, Ross SE (2016) Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling. Genesis 54:29-37. PMCID: PMC 4747253 Download Article
2015
Naito A, Muchhala KH, Trang J, Asatryan L, Trudell JR, Homanics GE, Alkana RL, Davies DL (2015) Manipulations of extracellular Loop 2 in alpha1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol. Neuroscience 297:68-77. PMCID: PMC PMC4428915 Download Article
Jaiswal MK, Keros S, Zhao M, Inan M, Schwartz TH, Anderson SA, Homanics GE, Goldstein PA (2015) Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor alpha4 subunit. Front Cell Neurosci 9:127. PMCID: PMC PMC4391265 Download Article
Finegersh A, Rompala GR, Martin DI, Homanics GE (2015) Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations. Alcohol 49:461-470. PMCID: PMC 4469624 Download Article
Finegersh A, Ferguson C, Maxwell S, Mazariegos D, Farrell D, Homanics GE (2015) Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. Front Mol Neurosci 8:39. PMCID: PMC PMC4524924 Download Article
Belmonte JC et al. (2015) Brains, Genes, and Primates. Neuron 86:617-631. PMCID: PMC 4425847 Download Article
2014
Zimmerman MW, McQueeney KE, Isenberg JS, Pitt BR, Wasserloos KA, Homanics GE, Lazo JS (2014) Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. J Biol Chem 289:5904-5913. PMCID: PMC 3937659 Download Article
Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L (2014) Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci 17:232-239. PMCID: PMC 4019963 Download Article
Peng Z, Zhang N, Chandra D, Homanics GE, Olsen RW, Houser CR (2014) Altered Localization of the delta Subunit of the GABAA Receptor in the Thalamus of alpha4 Subunit Knockout Mice. Neurochem Res 39:1104-1117. PMCID: PMC 4024081 Download Article
Naito A, Muchhala KH, Asatryan L, Homanics GE, Trudell JR, Perkins D, Davies DL, Alkana RL (2014) Glycine and GABAA Ultra-Sensitive Ethanol Receptors (USERs) as novel tools for alcohol and brain research. Mol Pharmacol 86:635-646. PMCID: PMC PMC4244596 Download Article
Mariqueo TA, Agurto A, Munoz B, San Martin L, Coronado C, Fernandez-Perez EJ, Murath P, Sanchez A, Homanics GE, Aguayo LG (2014) Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons. J Neurophysiol 111:1940-1948. PMCID: PMC 4044338 Download Article
Iyer SV, Chandra D, Homanics GE (2014) GABAA-R alpha4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofol. Neurochem Res 39:1048-1056. PMCID: PMC 3964144 Download Article
Horn CC, Wallisch WJ, Homanics GE, Williams JP (2014) Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Eur J Pharmacol 722:55-66. PMCID: PMC PMC3915298 Download Article
Finegersh A, Homanics GE (2014) Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex. Alcohol Clin Exp Res 38:1865-1873. PMCID: PMC 4107049 Download Article
Finegersh A, Homanics GE (2014) Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring. PLoS One 9:e99078. PMCID: PMC 4045990 Download Article
Cramer JM, Zimmerman MW, Thompson T, Homanics GE, Lazo JS, Lagasse E (2014) Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice. Stem Cell Res 13:164-171. PMCID: PMC 4090270 Download Article
Aguayo LG, Castro P, Mariqueo T, Munoz B, Xiong W, Zhang L, Lovinger DM, Homanics GE (2014) Altered sedative effects of ethanol in mice with alpha1 glycine receptor subunits that are insensitive to Gβγ modulation. Neuropsychopharmacology 39:2538-2548. PMCID: PMC PMC4207329 Download Article
2013
Zimmerman MW, Homanics GE, Lazo JS (2013) Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. PLoS One 8:e58300. PMCID: PMC 3610886 Download Article
Ferguson C, McKay M, Harris RA, Homanics GE (2013) Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation. Alcohol 47:595-599. PMCID: PMC 3844088 Download Article
den Hartog CR, Beckley JT, Smothers TC, Lench DH, Holseberg ZL, Fedarovich H, Gilstrap MJ, Homanics GE, Woodward JJ (2013) Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors. PLoS One 8:e80541. PMCID: PMC 3828265 Download Article
Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA (2013) Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication. Neuropharmacology 67C:46-56. PMCID: PMC 3562427 Download Article
2012
Sabaliauskas N, Shen H, Homanics GE, Smith SS, Aoki C (2012) Knockout of the gamma-aminobutyric acid receptor subunit alpha4 reduces functional delta-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty. Brain Res 1450:11-23. PMCID: PMC 3319511 Download Article
Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI, 2nd, Harris RA (2012) Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice. Anesthesiology 117:765-771. PMCID: PMC 3447119 Download Article
Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA (2012) Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. Journal of Pharmacology and Experimental Therapeutics 340:304-316. PMCID: PMC 3263968 Download Article
Blednov YA, Benavidez JM, Homanics GE, Harris RA (2012) Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit. Journal of Pharmacology and Experimental Therapeutics 340:317-329. PMCID: PMC 3263963 Download Article
2011
Werner DF, Swihart A, Rau V, Jia F, Borghese CM, McCracken ML, Iyer S, Fanselow MS, Oh I, Sonner JM, Eger EI, 2nd, Harrison NL, Harris RA, Homanics GE (2011) Inhaled anesthetic responses of recombinant receptors and knockin mice harboring alpha2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane. J Pharmacol Exp Ther 336:134-144. PMCID: PMC 3014300
Suryanarayanan A, Liang J, Meyer EM, Lindemeyer AK, Chandra D, Homanics GE, Sieghart W, Olsen RW, Spigelman I (2011) Subunit compensation and plasticity of synaptic GABA(A) receptors induced by ethanol in alpha4 subunit knockout mice. Front Neurosci 5:110. PMCID: PMC 3178803
Rau V, Oh I, Liao M, Bodarky C, Fanselow MS, Homanics GE, Sonner JM, Eger EI, 2nd (2011) Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane. Anesth Anal 113:500-504.
Quesada A, Bui PH, Homanics GE, Hankinson O, Handforth A (2011) Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. Eur J Pharmacol 659:30-36.
Iyer SV, Benavides RA, Chandra D, Cook JM, Rallapalli S, June HL, Homanics GE (2011) Alpha4-containing GABA(A) receptors are required for antagonism of ethanol-induced motor incoordination and hypnosis by the imidazobenzodiazepine Ro15-4513. Front Pharmacol 2:18. PMCID: PMC 3132666
Harris RA, Osterndorff-Kahanek E, Ponomarev I, Homanics GE, Blednov YA (2011) Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor alpha1 and alpha2 subunit knock-in mice. Neurosci Lett 488:31-35. PMCID: PMC 3033563
Duveau V, Laustela S, Barth L, Gianolini F, Vogt KE, Keist R, Chandra D, Homanics GE, Rudolph U, Fritschy JM (2011) Spatiotemporal specificity of GABA(A) receptor-mediated regulation of adult hippocampal neurogenesis. Eur J Neurosci 34:362-373.
Chang KY, Park YG, Park HY, Homanics GE, Kim J, Kim D (2011) Lack of Ca(V)3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor. Biochem Biophys Res Commun 410:19-23.
Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA (2011) Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive alpha2-containing GABA(A) receptors. J Pharmacol Exp Ther 336:145-154. PMCID: PMC 3014308
2010
Wilking JA, Hesterberg KG, Crouch EL, Homanics GE, Stitzel JA (2010) Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity. Pharmacogenet Genomics 20:121-130. PMCID: PMC PMC2919848
Moore MD, Cushman J, Chandra D, Homanics GE, Olsen RW, Fanselow MS (2010) Trace and contextual fear conditioning is enhanced in mice lacking the alpha4 subunit of the GABA(A) receptor. Neurobiol Learn Mem 93:383-387. PMCID: PMC PMCID: In Process
Jentarra GM, Olfers SL, Rice SG, Srivastava N, Homanics GE, Blue M, Naidu S, Narayanan V (2010) Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation. BMC Neurosci 11:19. PMCID: PMC 2836362
Haselkorn ML, Shellington D, Jackson E, Vagni VA, Janesko KL, Dubey RK, Gillespie DG, Cheng D, Bell MJ, Jenkins LW, Homanics GE, Schnermann J, Kochanek PM (2010) Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice. J Neurotrauma 27:901-910. PMCID: PMC PMC2943944
Handforth A, Homanics GE, Covey DF, Krishnan K, Lee JY, Sakimura K, Martin FC, Quesada A (2010) T-Type Calcium Channel Antagonists Suppress Tremor in Two Mouse Models of Essential Tremor. Neuropharmacology 59:380-387. PMCID: PMC PMC 3787716
Chandra D, Halonen LM, Linden AM, Procaccini C, Hellsten K, Homanics GE, Korpi ER (2010) Prototypic GABA(A) receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites. Neuropsychopharmacology 35:999-1007. PMCID: PMC PMC2823376
Blednov YA, Walker DL, Iyer SV, Homanics G, Harris AR (2010) Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol. Addict Biol 15:45-61. PMCID: PMC PMC3038569
2009
Zinnanti W, Lazovic J, Griffin K, Skvorak KJ, Paul HS, Homanics GE, Bewely M, Cheng KC, LaNoue K, Flanagan JM (2009) Dual mechanisms of brain injury and novel treatment strategy in maple syrup urine disease. Brain 132:903-918. PMCID: PMC 2668944
Ying S-W, Werner DF, Homanics GE, Harrison NL, Goldstein PA (2009) Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology 56:438-447. PMCID: PMC 2668243
Wiltgen BJ, Godsil B, Peng Z, Saab F, June HL, Van Lin M, Cook J, Houser CR, O’Dell TJ, Homanics GE, Fanselow M (2009) The α1 subunit of the GABAA receptor modulates fear learning and plasticity in the lateral amygdala. Front Behav Neurosci 3:37. PMCID: PMC 2769557
Werner DF, Swihart AR, Ferguson C, Lariviere WR, Harrison NL, Homanics GE (2009) Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors. Alcohol Clin Exp Res 33:289-299. PMCID: PMC 2786059
Skvorak K, Paul HS, Dorko K, Marongiu F, Ellis E, Chace D, Ferguson C, Gibson K, Homanics GE, Strom S (2009) Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease. Molecular Therapy 17:1266-1273. PMCID: PMC PMC2835204
Skvorak K, Hager E, Arning E, Bottiglieri T, Paul HS, Strom S, Homanics GE, Sun Q, Jansen E, Jackobs C, Gibson K (2009) Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormlities in murine intermediate Maple Syrup Urine Disease (iMSUD). BBA-Mol Basis Dis 1792:1004-1010. PMCID: PMC 2753721
Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI, 2nd, Fanselow MS, Homanics GE, Sonner JM (2009) Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg 109:1816-1822. PMCID: PMC 2895314
Herd MB, Foister N, Chandra D, Peden DR, Homanics GE, Brown VJ, Balfour DJ, Lambert JJ, Belelli D (2009) Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors. Eur J Neurosci 29:1177-1187. PMCID: PMC 2788206
Hentschke H, Benkwitz C, Banks MI, Perkins MG, Homanics GE, Pearce RA (2009) Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit. J Neurophysiol 102:3643-3655. PMCID: PMC 2804419
Halonen LM, Sinkkonen ST, Chandra D, Homanics GE, Korpi ER (2009) Brain regional distribution of GABA(A) receptors exhibiting atypical GABA agonism: roles of receptor subunits. Neurochem Int 55:389-396. PMCID: PMC 2760098
Gong H, He J, Lee JH, Mallick E, Gao X, Li S, Homanics GE, Xie W (2009) Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury. J Biol Chem 284:30113-30121. PMCID: PMC 2781566
Berry RB, Chandra D, Diaz Granados J, Homanics GE, Matthews DB (2009) Investigation of ethanol-induced impairment of spatial memory in γ2 heterozygous knockout mice. Neurosci Lett 455:84-87. PMCID: PMC 2699767
2008
Peden DR, Petitjean CM, Herd MB, Durakoglugil M, Rosahl TW, Wafford KA, Homanics GE, Belelli D, Fritschy JM, Lambert JJ (2008) Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. J Physiol 586:965-987. PMCID: PMC 2375643
Liang J, Suryanarayanan A, Chandra D, Homanics GE, Olsen RW, Spigelman I (2008) Functional consequences of GABAA receptor α4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells. Alcohol Clin Exp Res 32:19-26.
Jia F, Yue M, Chandra D, Keramidas A, Goldstein PA, Homanics GE, Harrison NL (2008) Taurine is a potent activator of extrasynaptic GABAA receptors in the thalamus. J Neurosci 28:106-115.
Jia F, Yue M, Chandra D, Goldstein PA, Homanics GE, Harrison NL (2008) Isoflurane is a potent modulator of extrasynaptic GABAA receptors in the thalamus. J Pharmacol Exp Ther 324:1127-1135.
Jia F, Chandra D, Homanics GE, Harrison NL (2008) Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus. J Pharmacol Exp Ther 326:475-482. PMCID: PMC 2669290
Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D (2008) The expression of GABAA β subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. J Physiol 586:989-1004. PMCID: PMC 2375644
DeLorey TM, Sahbaie P, Hashemi E, Homanics GE, Clark JD (2008) Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder. Behavioral Brain Research 187:207-220. PMCID: PMC 2684890
Chandra D, Werner DF, Olsen RW, Harrison NL, Homanics GE (2008) Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor α4 subunit knockout mice. Alcohol Clin Exp Res 32:10-18. PMCID: PMC 2896280
Berry RB, Werner DF, Wang XF, Mittleman G, Jablonski MM, Homanics GE, Matthews DB (2008) Mice with targeted genetic reductions of GABAA receptor α1 subunits display performance differences in Morris water maze tasks. Neurobiol Learn Mem 90:580-583. PMCID: PMC 2581787
2007
Winsky-Sommerer R, Vyazovskiy V, Homanics GE, Tobler I (2007) The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABAA δ-subunit containing receptors. Eur J Neurosci 25:1893-1899.
Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI, Homanics GE (2007) Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express α1 γ-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology 106:107-113.
Lovinger DM, Homanics GE (2007) Tonic for what ails us? high-affinity GABA(A) receptors and alcohol. Alcohol 41:139-143.
Kim JB, Atherley R, Werner DF, Homanics GE, Carstens E, Antognini JF (2007) Isoflurane depression of spinal nociceptive processing and minimum alveolar anesthetic concentrations are not attenuated in mice expressing isoflurane resistant γ-aminobutyric acid type A receptors. Neurosci Lett 420:209-212.
June Sr. HL, Foster KL, Eiler WJ, Goergen J, Cook JB, Johnson N, Mensah-Zoe B, Simmons JO, June Jr. HL, Yin W, Cook JM, Homanics GE (2007) Dopamine and benzodiazepine-dependent mechanisms regulate the ethanol-enhanced locomotor stimulation in GABAA α1 subunit null mutant mice. Neuropsychopharmacology 32:137-152.
Glykys J, Peng Z, Chandra D, Homanics GE, Houser CR, Mody I (2007) A novel naturally occuring GABAA receptor partnership with high sensitivity to ethanol. Nat Neurosci 10:40-48.
Ferguson C, Hardy SL, Werner DF, Hileman SM, DeLorey TM, Homanics GE (2007) New insight into the role of the β3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci:85.
2006
Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, Harris RA, Homanics GE (2006) Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. J Pharmacol Exp Ther 319:219-227.
Smith SS, Ruderman Y, Frye C, Homanics G, Yuan M (2006) Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5β-THP: a possible model of premenstrual dysphoric disorder. Psychopharmacology 186:323-333.
Skvorak K, Vissel B, Homanics GE (2006) Production of conditional point mutant knockin mice. Genesis 44:345-353.
Ponomarev I, Maiya R, Harnett MT, Schafer GL, Ryabinin AE, Blednov YA, Morikawa H, Boehm SL, 2nd, Homanics GE, Berman AE, Lodowski KH, Bergeson SE, Harris RA (2006) Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors. J Neurosci 26:5673-5683. PMCID: PMC 1894896
Ogris W, Lehner R, Fuchs K, Furtmuller B, Hoger H, Homanics GE, Sieghart W (2006) Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of α1-subunit deficient mice. J Neurochem 96:136-147.
Maison SF, Rosahl TW, Homanics GE, Liberman C (2006) Functional role of the cochlea’s GABAergic innervation: phenotypic analysis of mice lacking GABA(A) receptor subunits α1, α2,α5, α6, β2, β3, or δ. J Neurosci 26:10315-10326.
Kralic JE, Sidler C, Parpan F, Homanics GE, Morrow AL, Fritschy JM (2006) Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of GABAA receptor α1 subunit knockout mice. J Comp Neurol 495:408-421.
Kochanek PM, Vagni VA, Janesko KL, Washington CB, Crumrine PK, Garman RH, Jenkins LW, Clark RSB, Homanics GE, Dixon CE, Schnermann J, Jackson EK (2006) Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism 26:565-575.
Homanics GE, Skvorak K, Ferguson C, Watkins SC, Paul HS (2006) Production and characterization of murine models of classic and intermediate maple syrup urine disease. BMC Med Genet 7:33.
Elsen FP, Liljelund P, Werner DF, Olsen RW, Homanics GE, Harrison NL (2006) GABAA-R α1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice. Brain Res 1078:60-70.
Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE (2006) GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc Natl Acad Sci USA 103:15230-15235.
Borghese CM, Elsen FP, Werner DF, Topf N, Baron NV, Henderson LA, Boehm II SL, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL (2006) An isoflurane- and alcohol-insensitive mutant GABAA receptor α1 subunit with near normal apparent affinity for GABA: characterization in heterologous systems and production of knock-in mice. J Pharmacol Exp Ther 319:208-218.
Boehm II SL, Homanics GE, Blednov YA, Harris RA (2006) δ-subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisothiazolo-[5,4-c]pyridin-3-ol. Eur J Pharmacol 541:158-162.
2005
Wiltgen BJ, Sanders MJ, Ferguson C, Homanics GE, Fanselow MS (2005) Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAa receptor. Learn Mem 12:327-333.
Sonner JM, Cascio M, Xing Y, Fanselow MS, Kralic JE, Morrow AL, Korpi ER, Hardy S, Sloat B, Eger EI, Homanics GE (2005) α1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear. Mol Pharmacol 68:61-68.
Osterman JL, Kralic JE, O’buckley TK, Homanics GE, Morrow AL (2005) GABAA receptor α1 subunit knockout mice: A novel model of essential tremor. In: Animal Models of Movement Disorders (LeDoux MS, ed), pp 369-376. SanDiego: Elsevier, Inc.
Liljelund P, Handforth RA, Homanics GE, Olsen RW (2005) GABAA receptor β3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in β3 subunit levels, EEG, and behavior. Dev Brain Res 157:150-161.
Liljelund P, Ferguson C, Homanics GE, Olsen RW (2005) Long-term effects of diazepam treatment of epileptic GABAA receptor β3 subunit knockout mouse in early life depends. Epilep Res 66:99-115.
Kralic JE, Criswell HE, Osterman JL, O’Buckley TK, Wilkie ME, Matthews DB, Hamre K, Breese GR, Homanics GE, Morrow AL (2005) Genetic essential tremor in γ-aminobutyric acidA receptor α1 subunit knockout mice. J Clin Invest 115:774-779.
Homanics GE, Elsen FP, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Kralic J, Morrow AL, Harrison NL (2005) A gain-of-function mutation in the GABAA receptor produces synaptic and behavioral abnormalities in the mouse. Genes Brain Behav 4:10-19.
Handforth RA, DeLorey TM, Homanics GE, Olsen RW (2005) Pharmacologic evidence for abnormal thalamocortical functioning in GABAA receptor β3 subunit-deficient mice, a model of Angelman syndrome. Epilepsia 46:1860-1870.
Chandra D, Korpi ER, Miralles CP, de Blas AL, Homanics GE (2005) GABAa receptor γ2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. BMC Neurosci 6:30.
2004
Werner DF, Chandra D, Homanics GE (2004) Genetically engineered animals in alcohol research. In: Comprehensive Handbook of Alcohol Related Pathology (Preedy VR, Watson RR, eds), pp 1583-1596. London: Elsevier Science.
Uusi-Oukari M, Kosonen P, Homanics GE, Korpi ER (2004) Brain regional heterogeneity of pH effects on GABAAreceptor-associated [35S]TBPS binding. Neurochem Res 29:771-780.
Shannon EE, Shelton KL, Vivian JA, Yount I, Morgan AR, Homanics GE, Grant KA (2004) Discriminative stimulus effects of ethanol in mice lacking the γ-aminobutyric acid type A receptor δ subunit. Alcohol Clin Exp Res 28:906-913.
Panzanelli P, Homanics GE, Ottersen OP, Fritschy J-M, Sassoe-Pognetto M (2004) Pre- and postsynaptic GABAA receptors at reciprocal dendrodendritic synapses in the olfactory bulb. Eur J Neurosci 20:2945-2952.
2003
Spigelman I, Li Z, Liang J, Cagetti E, Samzadeh S, Mihalek RM, Homanics GE, Olsen RW (2003) Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABAA receptor δ subunit. J Neurophys 90:903-910.
Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eger EI (2003) Inhaled anesthetics and immobility: Mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg 97:718-740.
Sinkkonen ST, Homanics GE, Korpi ER (2003) Mouse models of Angelman syndrome, a neurodevelopmental disorder, display different brain regional GABAA receptor alterations. Neurosci Lett 340:205-208.
Ramadan E, Fu Z, Losi G, Homanics GE, Neale JH, Vicini S (2003) GABAA receptor β3 subunit deletion decreases α2 subunit expression and accelerates inhibitory synaptic currents in cortical neurons in culture. J Neurophysiol 89:128-134.
Porcello DM, Huntsman MM, Mihalek RM, Homanics GE, Huguenard JR (2003) Intact fast synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit. J Neurophysiol 89:1378-1386.
Kralic JE, Wheeler M, Renzi K, Ferguson C, O’Buckley TK, Grobin AC, Morrow AL, Homanics GE (2003) Deletion of GABAa receptor alpha-1 subunit-containing receptors alters responses to ethanol and other anesthetics. J Pharmacol Exp Ther 305:600-607.
2002
Wisor JP, DeLorey TM, Homanics GE, Edgar DM (2002) Sleep states and sleep electroencephalographic spectral power in mice lacking the b3 subunit of the GABAa receptor. Brain Res 955:221-228.
Vicini S, Losi G, Homanics GE (2002) GABAa receptor δ subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons. Neuropharmacology 43:646-650.
Spigelman I, Li Z, Banerjee PK, Mihalek RM, Homanics GE, Olsen RW (2002) Behavior and physiology of mice lacking the GABAA-receptor δ subunit. Epilepsia 43 Suppl 5:3-8.
Quinlan JJ, Ferguson C, Jester K, Firestone LL, Homanics GE (2002) Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics. Anesth Analg 95:578-582.
Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR (2002) GABAA receptor changes in δ subunit-deficient mice: altered expression of α4 and γ2 subunits in the forebrain. J Comp Neurol 446:179-197.
Kralic JE, O’Buckley TK, Khisti RT, Hodge CW, Homanics GE, Morrow AL (2002) GABAa receptor alpha-1 subunit deletion alters benzodiazepine receptor assembly, pharmacological properties and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology 43:685-694.
Kralic JE, Korpi ER, O’Buckley, Homanics GE, Morrow AL (2002) Molecular and pharmacologic characterization of GABAA receptor alpha-1 subunit knockout mice. J Pharmacol Exp Ther 302:1037-1045.
Korpi ER, Mihalek RM, Sinkkonen ST, Hauer B, Hevers W, Homanics GE, Sieghart W, Lüddens H (2002) Altered receptor subtypes in the forebrain of GABAA receptor δ subunit-deficient mice: recruitment of γ2 subunits. Neuroscience 109:733-743.
Koo J-W, Homanics GE, Balaban CD (2002) Hypoplasia of spiral and Scarpa’s ganglion cells in GABAa receptor β3 subunit knockout mice. Hearing Research 167:71-80.
Homanics GE (2002) Knockout and knockin mice. In: Methods for Alcohol-Related Neuroscience Research (Liu Y, Lovinger DM, eds), pp 31-60. Boca Raton: CRC Press LLC.
Homanics GE (2002) Dissection of putative anesthetic targets with genetically engineered mice. In: Molecular and Basic Mechanisms of Anesthesia (Urban B, Barann M, eds), pp 526-527. Berlin: Pabst Science Publishers.
Homanics GE, Firestone LL (2002) Genetic dissection of anesthetic action. In: Contemporary Clinical Neuroscience: Neural Mechanisms of Anesthesia (Antognini J, Carstens, Raines D, eds), pp 249-261. Totowa, NJ: Humana Press Inc.
Homanics GE, Xu Y, Tang P (2002) Integrated approaches to the action of general anesthetics and alcohol. Physiology and Behavior 77:495-499.
Goldstein PA, Elsen FP, Ying S-W, Ferguson C, Homanics GE, Harrison NL (2002) Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABAA receptor α1 subunit. J Neurophysiol 88:3208-3217.
2001
Wong SME, Cheng G, Homanics GE, Kendig JJ (2001) Enflurane actions on spinal cords from mice that lack the β3 subunit of the GABAa receptor. Anesthesiology 95:154-164.
Vicini S, Ferguson C, Prybylowski K, Kralic J, Morrow AL, Homanics GE (2001) GABAA receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci 21:3009-3016.
Ugarte SD, Homanics GE, Hammond DL (2001) Effect of embryonic knock-down of GABAa receptors on the levels of monoamines and their metabolites in the CNS of the mouse. Brain Res 904:290-297.
Tretter V, Hauer B, Nusser Z, Mihalek RM, Hoger H, Homanics GE, Somogyi P, Sieghart W (2001) Targeted disruption of the GABAA receptor delta subunit gene leads to an upregulation of gamma2 subunit-containing receptors in cerebellar granule cells. J Biol Chem 276:10532-10538.
Tobet SA, Dellovade TL, Parker K, Homanics GE (2001) Positioning estrogen receptor alpha containing cells during hypothalamic development. In: Neuroplasticity, Development and Steroid Hormone Action (Handa RJ, Hayashi S, Terasawa E, Kawata M, eds), pp 59-72. FL: CRC Press LLC.
Sinkkonen ST, Mihalek RM, Homanics GE, Korpi ER (2001) Altered atypical coupling of γ-aminobutyric acid type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines. Mol Brain Res 86:179-183.
Nusser Z, Kay LM, Laurent G, Homanics GE, Mody I (2001) Disruption of GABAa receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb network. Jounal of Neurophysiology 86:2823-2833.
Mihalek RM, Bowers BJ, Wehner JM, Kralic JE, VanDoren MJ, Morrow AL, Homanics GE (2001) GABAa-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol. Alcohol Clin Exp Res 25:1708-1718.
Laposky AD, Homanics GE, Basile A, Mendelson WB (2001) Deletion of the GABAa receptor β3 subunit eliminates the hypnotic actions of oleamide in mice. Neuroreport 12:4143-4147.
Dellovade TL, Ross ED, Ferguson C, Homanics GE, Tobet SA (2001) GABA influences the development of the ventromedial nucleus of the hypothalamus. J Neurobiol 49:264-276.
2000
Uusi-Oukari M, Heikkila J, Sinkkonen ST, Makela R, Hauer B, Homanics GE, Sieghart W, Wisden W, Korpi ER (2000) Long-range interactions in neuronal gene expression: evidence from neomycin gene insertions in the GABAa receptor β2-α6-α1-γ2 gene cluster. Mol Cell Neurosci 16:34-41.
Ugarte SD, Homanics GE, Firestone LL, Hammond DL (2000) Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the b3 subunit of the GABAa receptor. Neuroscience 95:795-806.
Quinlan JJ, Firestone LL, Homanics GE (2000) Mice lacking the long splice variant of the g2 subunit of the GABAa receptor are more sensitive to benzodiazepines. Pharmacol Biochem Behav 66:371-374.
Olsen RW, Homanics GE (2000) Structure and function of GABAa receptors: Insights from mutant and knockout mice. In: GABA in the Nervous System: The View at Fifty Years (Martin DL, Olsen RW, eds), pp 81-96. Philadelphia, PA: Lippincott, Williams, & Wilkins.
Homanics GE (2000) Gene targeting strategies in the analysis of alcohol and anesthetic mechanisms. In: Genetic Manipulation of Receptor Expression and Function (Accili D, ed), pp 93-110. New York, NY: John Wiley & Sons, Inc.
Firestone LL, Korpi ER, Niemi L, Rosenberg PH, Homanics GE, Quinlan JJ (2000) Halothane and desflurane requirements in alcohol-tolerant and -nontolerant rats. British Journal of Anaesthesia 85:757-762.
1999
Schwartz DR, Homanics GE, Hoyt DG, Kline E, Abernathy J, Lazo JS (1999) The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. Proc Natl Acad Sci USA 96:4680-4685.
Resnick A, Homanics GE, Jung B, Peris J (1999) Increased acute cocaine sensitivity and decreased cocaine sensitization in GABAa b3 subunit knockout mice. J Neurochem 73:1539-1548.
Mihalek RM, Banjeree PK, Korpi E, Quinlan JJ, Firestone LL, Mi Z-P, Lagenaur C, Tretter V, Sieghart W, Anagnostaras S, Sage JR, Fanselow M, Guidotti A, Spigelman I, Li A, DeLorey TM, Olsen RW, Homanics GE (1999) Attenuated sensitivity to neuroactive steroids in GABA type A receptor delta subunit knockout mice. Proc Natl Acad Sci USA 96:12905-12910.
Huntsman MM, Porcello DM, Homanics GE, DeLorey TM, Huguenard JR (1999) Reciprocal inhibitory connections control network synchrony in the mammalian thalamus. Science 283:541-543.
Homanics GE, Quinlan JJ, Firestone LL (1999) Pharmacologic and behavioral responses of inbred C57BL/6J and Strain 129/SvJ mouse lines. Pharmacol Biochem Behav 63:21-26.
Homanics GE, Harrison NL, Quinlan JJ, Krasowski MD, Rick CEM, deBlas AL, Mehta A, Kist F, Mihalek RM, Aul JJ, Firestone LL (1999) Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the g2 subunit of the g-aminobutyrate type A receptor. Neuropharmacology 38:253-265.
DeLorey TM, Handforth A, Homanics GE, Minassian BA, Delgado-Escueta AV, Olsen RW (1999) The epilepsy of the GABAA receptor b3 subunit knockout mouse: Comparison to the epilepsy of Angelman syndrome. In: Genetics of Focal Epilepsy: Clinical Aspects and Molecular Biology (Berkovic SF, Genton P, Hirsch E, Pichard F, eds), pp 267-274. London: John Libbey & Co., Ltd.
1998
Quinlan JJ, Homanics GE, Firestone LL (1998) Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor. Anesthesiology 88:775-780.
Krasowski M, Rick C, Harrison N, Firestone L, Homanics G (1998) A deficit of functional GABA-A receptors in neurons of β3 subunit knockout mice. Neurosci Lett 240:81-84.
Homanics GE, Hiller-Sturmhofel S (1998) New genetic technologies in alcohol research. Alcohol Health and Research World 21:298-309.
Homanics GE, Quinlan JJ, Mihalek R, Firestone LL (1998) Genetic dissection of the molecular target(s) of anesthetics with the gene knockout approach in mice. Toxicol Lett 100-101:301-307.
Homanics GE, Quinlan JJ, Mihalek RM, Firestone LL (1998) Alcohol and anesthetic mechanisms in genetically engineered mice. Frontiers in Bioscience 3:d548-558.
Homanics GE, Le NQ, Kist F, Mihalek RM, Hart AR, Quinlan JJ (1998) Ethanol tolerance and withdrawal responses in GABAA receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and Strain 129/SvJ mice. Alcohol Clin Exp Res 22:259-265.
DeLorey TM, Handforth A, Homanics GE, Minassian BA, Anagnostaras SG, Asatourian A, Ellison G, Fenslow MS, Delgado-Escueta AV, Olsen RW (1998) Mice lacking the β3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J Neurosci 18:8505-8514.
1997
Mäkelä R, Uusioukari M, Homanics GE, Quinlan JJ, Firestone LL, Wisden W, Korpi ER (1997) Cerebellar gamma-aminobutyric acid type A receptors: Pharmacological subtypes revealed by mutant mouse lines. Mol Pharmacol 52:380-388.
Homanics GE, Ferguson C, Quinlan JJ, Daggett J, Snyder K, Lagenaur C, Mi ZP, Wang XH, Grayson DR, Firestone LL (1997) Gene knockout of the α6 subunit of the γ-aminobutyric acid type A receptor: Lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol Pharmacol 51:588-596.
Homanics GE, Delorey TM, Firestone LL, Quinlan JJ, Handforth A, Harrison NL, Krasowski MD, Rick CEM, Korpi ER, Makela R, Brilliant MH, Hagiwara N, Ferguson C, Snyder K, Olsen RW (1997) Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc Natl Acad Sci USA 94:4143-4148.
1995
Mueller GM, McKenzie LR, Homanics GE, Watkins SC, Robbins PD, Paul HS (1995) Complementation of defective leucine decarboxylation in fibroblasts from a maple syrup urine disease patient by retrovirus-mediated gene transfer. Gene Therapy 2:461-468.
Homanics GE, Maeda N, Traber MG, Kayden HJ, Dehart DB, Sulik KK (1995) Exencephaly and hydrocephaly in mice with targeted modification of the apolipoprotein B (Apob) gene. Teratology 51:1-10.
Homanics GE, de Silva HV, Osada J, Zhang SH, Wong H, Borensztajn J, Maeda N (1995) Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene. J Biol Chem 270:2974-2980.
Firestone L, Quinlan J, Homanics G (1995) Role of GABAA receptor subtypes in the pharmacology of general anesthetics. Curr Opin Anesth 8:311-314.
1993
Homanics GE, Smith TJ, Zhang SH, Lee D, Young SG, Maeda N (1993) Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proc Natl Acad Sci USA 90:2389-2393.
1991
Jacobs AL, Homanics GE, Silver WJ (1991) Activity of phospholipase C in ovine luteal tissue in response to PGF2 alpha, PGE2 and luteinizing hormone. Prostaglandins 41:495-500.
Homanics GE (1991) Morphological abnormalities, neonatal mortality, and reproductive abnormalities in mice transgenic for diphtheria toxin genes that are driven by the promoter for adipocyte lipid binding protein. Dev Genet 12:371-379.
1990
Didion BA, Pomp D, Martin MJ, Homanics GE, Markert CL (1990) Observations on the cooling and cryopreservation of pig oocytes at the germinal vesicle stage. Journal of Animal Science 68:2803-2810.
1988
Silvia WJ, Homanics GE (1988) Role of phospholipase C in mediating oxytocin-induced release of prostaglandin F2 alpha from ovine endometrial tissue. Prostaglandins 35:535-548.
Homanics GE, Silvia WJ (1988) Effects of progesterone and estradiol-17 beta on uterine secretion of prostaglandin F2 alpha in response to oxytocin in ovariectomized ewes. Biol Reprod 38:804-811.